Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50405885
Substrate
n/a
Meas. Tech.
ChEMBL_2266077
Ki
47±n/a nM
Citation
 Marapaka, AK; Nocentini, A; Youse, MS; An, W; Holly, KJ; Das, C; Yadav, R; Seleem, MN; Supuran, CT; Flaherty, DP Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to  ACS Med Chem Lett 14:103-109 (2023) [PubMed] 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CAH2_HUMAN | CA2 | CA-II | CAC | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Human
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50405885
Synonyms:
CHEMBL4749585
Type:
Small organic molecule
Emp. Form.:
C4H8N4O2S2
Mol. Mass.:
208.27
SMILES:
CCNc1nnc(s1)S(N)(=O)=O
Structure:
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