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Target
Carbonic anhydrase 2
Ligand
BDBM16669
Substrate
n/a
Meas. Tech.
ChEMBL_2266077
Ki
29±n/a nM
Citation
 Marapaka, AK; Nocentini, A; Youse, MS; An, W; Holly, KJ; Das, C; Yadav, R; Seleem, MN; Supuran, CT; Flaherty, DP Structural Characterization of Thiadiazolesulfonamide Inhibitors Bound to  ACS Med Chem Lett 14:103-109 (2023) [PubMed] 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CAH2_HUMAN | CA2 | CA-II | CAC | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Human
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM16669
Synonyms:
N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)benzamide | CHEMBL281376 | heterocyclic sulfonamide compound 34
Type:
Small organic molecule
Emp. Form.:
C9H8N4O3S2
Mol. Mass.:
284.00
SMILES:
NS(=O)(=O)c1nnc(NC(=O)c2ccccc2)s1
Structure:
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