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Target
Aldehyde dehydrogenase family 1 member A3
Ligand
BDBM50406343
Substrate
n/a
Meas. Tech.
ChEMBL_2266496
IC50
<100±n/a nM
Citation
 Kargbo, RB Discovery of Selective Aldehyde Dehydrogenase Inhibitors for the Treatment of Cancer. ACS Med Chem Lett 14:131-132 (2023) [PubMed] 
Target
Name:
Aldehyde dehydrogenase family 1 member A3
Synonyms:
Aldehyde dehydrogenase 6 | Aldehyde dehydrogenase family 1 member A3 | RALDH-3 | RalDH3 | Retinaldehyde dehydrogenase 3 | AL1A3_HUMAN | ALDH1A3 | ALDH6
Type:
PROTEIN
Mol. Mass.:
56110.85
Organism:
Human
Description:
ChEMBL_109700
Residue:
512
Sequence:
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
  
Inhibitor
Name:
BDBM50406343
Synonyms:
CHEMBL5269320
Type:
Small organic molecule
Emp. Form.:
C21H23FN2O2
Mol. Mass.:
354.43
SMILES:
Fc1cccc(c1)[C@H]1CCCN1CCOc1ccc2NC(=O)CCc2c1 |r|
Structure:
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