Reaction Details Report a problem with these data
Target
Alpha-ketoglutarate-dependent dioxygenase AlkB
Ligand
BDBM50416550
Substrate
n/a
Meas. Tech.
ChEMBL_2269247
IC50
168800±n/a nM
Citation
 Perry, GS; Das, M; Woon, ECY Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets. J Med Chem 64:16974-17003 (2021) [PubMed] 
Target
Name:
Alpha-ketoglutarate-dependent dioxygenase AlkB
Synonyms:
1.14.11.33 | aidD | alkB | Alkylated DNA repair protein AlkB | Alpha-ketoglutarate-dependent dioxygenase AlkB | DNA oxidative demethylase AlkB
Type:
PROTEIN
Mol. Mass.:
24079.78
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_120873
Residue:
216
Sequence:
MLDLFADAEPWQEPLAAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCGHLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPDACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPLKRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAGKKE
  
Inhibitor
Name:
BDBM50416550
Synonyms:
CHEMBL5274121
Type:
Small organic molecule
Emp. Form.:
C10H9N3O4
Mol. Mass.:
235.20
SMILES:
c1cc(cnc1)C(=O)NNC(=O)/C=C/C(=O)O
Structure:
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