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Target
Dual specificity protein kinase CLK1
Ligand
BDBM50363167
Substrate
n/a
Meas. Tech.
ChEMBL_2275479
Ki
140±n/a nM
Citation
 Beato, A; Gori, A; Boucherle, B; Peuchmaur, M; Haudecoeur, R β-Carboline as a Privileged Scaffold for Multitarget Strategies in Alzheimer's Disease Therapy. J Med Chem 64:1392-1422 (2021) [PubMed] 
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC2-like kinase 1 (CLK1) | CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1 | CLK1_HUMAN | CLK1 | CLK
Type:
Protein
Mol. Mass.:
57322.21
Organism:
Human
Description:
P49759
Residue:
484
Sequence:
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
  
Inhibitor
Name:
BDBM50363167
Synonyms:
CHEMBL1945559
Type:
Small organic molecule
Emp. Form.:
C17H16Cl2N4O
Mol. Mass.:
n/a
SMILES:
Cn1c2c(C(C#N)C3(CCNCC3)NC2=O)c2ccc(Cl)c(Cl)c12
Structure:
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