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Target
A disintegrin and metalloproteinase with thrombospondin motifs 4
Ligand
BDBM50045936
Substrate
n/a
Meas. Tech.
ChEMBL_2277779
Ki
2680±n/a nM
Citation
 Cuffaro, D; Ciccone, L; Rossello, A; Nuti, E; Santamaria, S Targeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition. J Med Chem 65:13505-13532 (2022) [PubMed] 
Target
Name:
A disintegrin and metalloproteinase with thrombospondin motifs 4
Synonyms:
Aggrecanase-1 | Metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) | A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) | ATS4_HUMAN | ADAMTS4 | KIAA0688
Type:
Enzyme
Mol. Mass.:
90214.54
Organism:
Human
Description:
O75173
Residue:
837
Sequence:
MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK
  
Inhibitor
Name:
BDBM50045936
Synonyms:
CHEMBL69863 | 4-(3,5-dihydroxystyryl)benzene-1,2-diol | 4-[2-(3,5-dihydroxyphenyl)-(E)-1-ethenyl]-1,2-benzenediol(Piceatannol) | NSC-365798 | 3,4,3',5'-tetrahydroxy-trans-stilbene | 3,4,3',5'-tetrahydroxystillbene | (E)-Piceatannol | piceatanol | cid_667639 | trans-3,3',4,5'-tetrahydroxystilbene | 4-[2-(3,5-dihydroxyphenyl)-(E)-1-ethenyl]-1,2-benzenediol | 3,3',4,5'-tetrahydroxystilbene | (E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol | 4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,2-diol | 4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,2-diol(Piceatannol) | US11866416, Example 8
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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