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Target
Neutrophil elastase
Ligand
BDBM50516762
Substrate
n/a
Meas. Tech.
ChEMBL_2281371
IC50
2700±n/a nM
Citation
 Kim, HR; Tagirasa, R; Yoo, E Covalent Small Molecule Immunomodulators Targeting the Protease Active Site. J Med Chem 64:5291-5322 (2021) [PubMed] 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin | Leukocyte elastase | ELNE_HUMAN | ELANE | ELA2
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Human
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50516762
Synonyms:
CHEMBL4474485
Type:
Small organic molecule
Emp. Form.:
C12H11BN2OS
Mol. Mass.:
242.11
SMILES:
OB1N(Cc2ccccc2)N=Cc2ccsc12 |c:11|
Structure:
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