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Target
Eukaryotic initiation factor 4A-I
Ligand
BDBM50610971
Substrate
n/a
Meas. Tech.
ChEMBL_2282705
EC50
27460±n/a nM
Citation
 Zerio, CJ; Cunningham, TA; Tulino, AS; Alimusa, EA; Buckley, TM; Moore, KT; Dodson, M; Wilson, NC; Ambrose, AJ; Shi, T; Sivinski, J; Essegian, DJ; Zhang, DD; Schürer, SC; Schatz, JH; Chapman, E Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action. J Med Chem 64:15727-15746 (2021) [PubMed] 
Target
Name:
Eukaryotic initiation factor 4A-I
Synonyms:
ATP-dependent RNA helicase eIF4A-1 | eIF-4A-I | eIF4A-I | IF4A1_HUMAN | EIF4A1 | DDX2A | EIF4A
Type:
PROTEIN
Mol. Mass.:
46146.87
Organism:
Human
Description:
ChEMBL_864983
Residue:
406
Sequence:
MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
  
Inhibitor
Name:
BDBM50610971
Synonyms:
CHEMBL5290937
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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