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Target
Cytochrome P450 2C19
Ligand
BDBM50614230
Substrate
n/a
Meas. Tech.
ChEMBL_2296119
IC50
>25000±n/a nM
Citation
 Poulter, S; Austin, N; Armstrong, R; Barnes, M; Bucknell, SJ; Higueruelo, A; Banerjee, J; Mead, A; Mould, R; MacSweeney, C; O'Brien, MA; Stott, LA; Watson, SP The Identification of GPR52 Agonist HTL0041178, a Potential Therapy for Schizophrenia and Related Psychiatric Disorders. ACS Med Chem Lett 14:499-505 (2023) [PubMed] 
Target
Name:
Cytochrome P450 2C19
Synonyms:
(S)-limonene 6-monooxygenase | Cytochrome P450-11A | P450-254C | Mephenytoin 4-hydroxylase | (S)-limonene 7-monooxygenase | Cytochrome P450 2C19 (CYP2C19) | CYP2C19 | CYPIIC17 | (R)-limonene 6-monooxygenase | CYPIIC19 | Fenbendazole monooxygenase (4'-hydroxylating) | CP2CJ_HUMAN | Cytochrome P450 2C19 [I331V] | Cytochrome P450-254C | P450-11A
Type:
Enzyme
Mol. Mass.:
55935.47
Organism:
Human
Description:
P33261
Residue:
490
Sequence:
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV
  
Inhibitor
Name:
BDBM50614230
Synonyms:
CHEMBL5284353
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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