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Target
Acidic mammalian chitinase
Ligand
BDBM50614252
Substrate
n/a
Meas. Tech.
ChEMBL_2296174
Ki
8300±n/a nM
Citation
 Balestri, LJI; Trivisani, CI; Orofino, F; Fiorucci, D; Truglio, GI; D'Agostino, I; Poggialini, F; Botta, L; Docquier, JD; Dreassi, E Discovery and Optimization of a Novel Macrocyclic Amidinourea Series Active as Acidic Mammalian Chitinase Inhibitors. ACS Med Chem Lett 14:417-424 (2023) [PubMed] 
Target
Name:
Acidic mammalian chitinase
Synonyms:
AMCase | Lung-specific protein TSA1902 | CHIA_HUMAN | CHIA | Acidic mammalian chitinase (AMCase)
Type:
Protein
Mol. Mass.:
52266.66
Organism:
Human
Description:
Q9BZP6
Residue:
476
Sequence:
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
  
Inhibitor
Name:
BDBM50614252
Synonyms:
CHEMBL5283905
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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