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Target
Matrix metalloproteinase-14
Ligand
BDBM32188
Substrate
n/a
Meas. Tech.
ChEMBL_2298935
Kd
1200±n/a nM
Citation
 Lee, H; Youn, I; Demissie, R; Vaid, TM; Che, CT; Azar, DT; Han, KY Identification of small molecule inhibitors against MMP-14 via High-Throughput screening. Bioorg Med Chem 85:0 (2023) [PubMed] 
Target
Name:
Matrix metalloproteinase-14
Synonyms:
MMP-X1 | MTMMP1 | Matrix Metalloproteinase-14 (MMP-14) | MT1-MMP | Membrane-type matrix metalloproteinase 1 | Matrix metalloproteinase-14 | MMP-14 | MT-MMP 1 | MT1MMP | Matrix metalloproteinase 14 | Membrane-type-1 matrix metalloproteinase | MMP14_HUMAN | MMP14 | Matrix metalloproteinase-14 (MMP14)
Type:
Protein
Mol. Mass.:
65900.19
Organism:
Human
Description:
P50281
Residue:
582
Sequence:
MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
  
Inhibitor
Name:
BDBM32188
Synonyms:
cid_2788 | TG2-36-2 | CLIOQUINOL | Clioquinol (CQ) | US12377086, Compound 48
Type:
Small organic molecule
Emp. Form.:
C9H5ClINO
Mol. Mass.:
304.91
SMILES:
c1cc2c(cc(c(c2nc1)O)I)Cl
Structure:
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