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Target
Matrix metalloproteinase-14
Ligand
BDBM32147
Substrate
n/a
Meas. Tech.
ChEMBL_2298935
Kd
2400±n/a nM
Citation
 Lee, H; Youn, I; Demissie, R; Vaid, TM; Che, CT; Azar, DT; Han, KY Identification of small molecule inhibitors against MMP-14 via High-Throughput screening. Bioorg Med Chem 85:0 (2023) [PubMed] 
Target
Name:
Matrix metalloproteinase-14
Synonyms:
MMP-X1 | MTMMP1 | Matrix Metalloproteinase-14 (MMP-14) | MT1-MMP | Membrane-type matrix metalloproteinase 1 | Matrix metalloproteinase-14 | MMP-14 | MT-MMP 1 | MT1MMP | Matrix metalloproteinase 14 | Membrane-type-1 matrix metalloproteinase | MMP14_HUMAN | MMP14 | Matrix metalloproteinase-14 (MMP14)
Type:
Protein
Mol. Mass.:
65900.19
Organism:
Human
Description:
P50281
Residue:
582
Sequence:
MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
  
Inhibitor
Name:
BDBM32147
Synonyms:
AS-229 | cid_2722 | CHLOROXINE | US12377086, Compound 47
Type:
Small organic molecule
Emp. Form.:
C9H5Cl2NO
Mol. Mass.:
212.97
SMILES:
Oc1c(Cl)cc(Cl)c2cccnc12
Structure:
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