Reaction Details Report a problem with these data
Target
Aldehyde dehydrogenase family 1 member A3
Ligand
BDBM50459608
Substrate
n/a
Meas. Tech.
ChEMBL_2299643
IC50
187±n/a nM
Citation
 Beers, JL; Authement, AK; Isoherranen, N; Jackson, KD Cytosolic Enzymes Generate Cannabinoid Metabolites 7-Carboxycannabidiol and 11-Nor-9-carboxytetrahydrocannabinol. ACS Med Chem Lett 14:614-620 (2023) [PubMed] 
Target
Name:
Aldehyde dehydrogenase family 1 member A3
Synonyms:
Aldehyde dehydrogenase 6 | Aldehyde dehydrogenase family 1 member A3 | RALDH-3 | RalDH3 | Retinaldehyde dehydrogenase 3 | AL1A3_HUMAN | ALDH1A3 | ALDH6
Type:
PROTEIN
Mol. Mass.:
56110.85
Organism:
Human
Description:
ChEMBL_109700
Residue:
512
Sequence:
MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLGDKNP
  
Inhibitor
Name:
BDBM50459608
Synonyms:
CHEMBL3276621 | CHEBI:90441
Type:
Small organic molecule
Emp. Form.:
C12H20Cl4N2O2
Mol. Mass.:
366.12
SMILES:
C(CCCCNC(=O)C(Cl)Cl)CCCNC(=O)C(Cl)Cl
Structure:
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