Reaction Details Report a problem with these data
Target
Target of rapamycin complex subunit LST8
Ligand
BDBM50088378
Substrate
n/a
Meas. Tech.
ChEMBL_2306958
IC50
>1000±n/a nM
Citation
 Burnett, GL; Yang, YC; Aggen, JB; Pitzen, J; Gliedt, MK; Semko, CM; Marquez, A; Evans, JW; Wang, G; Won, WS; Tomlinson, ACA; Kiss, G; Tzitzilonis, C; Thottumkara, AP; Cregg, J; Mellem, KT; Choi, JS; Lee, JC; Zhao, Y; Lee, BJ; Meyerowitz, JG; Knox, JE; Jiang, J; Wang, Z; Wildes, D; Wang, Z; Singh, M; Smith, JAM; Gill, AL Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors. J Med Chem 66:149-169 (2023) [PubMed] 
Target
Name:
Target of rapamycin complex subunit LST8
Synonyms:
G protein beta subunit-like | Gable | Mammalian lethal with SEC13 protein 8 | Protein GbetaL | TORC subunit LST8 | Target of rapamycin complex subunit LST8 | LST8_HUMAN | MLST8 | GBL | LST8
Type:
PROTEIN
Mol. Mass.:
35871.25
Organism:
Human
Description:
ChEMBL_118692
Residue:
326
Sequence:
MNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDSQVNALEVTPDRSMIAAAGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYTGGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQAELIVGDQSGAIHIWDLKTDHNEQLIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFSPDSTLLATCSADQTCKIWRTSNFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSDNLARLWCVETGEIKREYGGHQKAVVCLAFNDSVLG
  
Inhibitor
Name:
BDBM50088378
Synonyms:
CHEBI:68478 | Afinitor | Afinitor Disperz | Everolimus | RAD001 | Zortress | US12091424, Example RAD001
Type:
Small organic molecule
Emp. Form.:
C53H83NO14
Mol. Mass.:
957.58
SMILES:
[H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N1CCCC[C@@]1([H])C(=O)O[C@@]([H])(CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C2)OC)[C@H](C)C[C@@H]1CC[C@@H](OCCO)[C@@H](C1)OC |r,c:32,51,t:47,49|
Structure:
Search PDB for entries with ligand similarity: