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Target
Bromodomain-containing protein 4
Ligand
BDBM50365262
Substrate
n/a
Meas. Tech.
ChEMBL_2307823
IC50
5.2±n/a nM
Citation
 Zerio, CJ; Sivinski, J; Wijeratne, EMK; Xu, YM; Ngo, DT; Ambrose, AJ; Villa-Celis, L; Ghadirian, N; Clarkson, MW; Zhang, DD; Horton, NC; Gunatilaka, AAL; Fromme, R; Chapman, E Physachenolide C is a Potent, Selective BET Inhibitor. J Med Chem 66:913-933 (2023) [PubMed] 
Target
Name:
Bromodomain-containing protein 4
Synonyms:
BRD4_HUMAN | BRD4 | HUNK1 | Bromodomain-containing protein 4 (BRD4) | Protein HUNK1
Type:
Protein
Mol. Mass.:
152264.84
Organism:
Human
Description:
O60885
Residue:
1362
Sequence:
MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF
  
Inhibitor
Name:
BDBM50365262
Synonyms:
CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 | US9695172, JQ1 | JQ1 | US10124009, Compound (S)-JQ1 | US10202360, Example JQ-1 | US10308662, Compound JQ-1 | US10407441, Compound (S)-JQ1 | US10617680, Example JQ-1 | US10925881, Name (S)-JQ1 | US10881668, Compound JQ1 | US11020380, Example JQ-1 | (+)-JQ1 | US11078188, Example (+)-JQ1 | US11466034, Example (+)-JQ1 | US11279703, TABLE 6.180 | US11427593, Compound JQ1 | US20250084096, Compound A | US20250221977, Compound JQ1
Type:
Small organic molecule
Emp. Form.:
C23H25ClN4O2S
Mol. Mass.:
n/a
SMILES:
Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14|
Structure:
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