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Target
Bromodomain-containing protein 3
Ligand
BDBM50616257
Substrate
n/a
Meas. Tech.
ChEMBL_2307843
IC50
4256±n/a nM
Citation
 Zerio, CJ; Sivinski, J; Wijeratne, EMK; Xu, YM; Ngo, DT; Ambrose, AJ; Villa-Celis, L; Ghadirian, N; Clarkson, MW; Zhang, DD; Horton, NC; Gunatilaka, AAL; Fromme, R; Chapman, E Physachenolide C is a Potent, Selective BET Inhibitor. J Med Chem 66:913-933 (2023) [PubMed] 
Target
Name:
Bromodomain-containing protein 3
Synonyms:
Bromodomain-containing protein 3 | RING3-like protein | Bromodomain-containing protein 3 (BRD3) | BRD3_HUMAN | BRD3 | KIAA0043 | RING3L | Bromodomain and extra-terminal motif (BET)
Type:
Protein
Mol. Mass.:
79571.81
Organism:
Human
Description:
Q15059
Residue:
726
Sequence:
MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDSE
  
Inhibitor
Name:
BDBM50616257
Synonyms:
CHEMBL3605566
Type:
Small organic molecule
Emp. Form.:
C30H40O9
Mol. Mass.:
544.64
SMILES:
[H][C@]12C[C@]3([H])[C@]([H])(CC[C@@]4(COC(C)=O)[C@@]3(O)CC[C@@]4(O)[C@@](C)(O)[C@@]3([H])CC(C)=C(C)C(=O)O3)[C@@]3(C)C(=O)C=CC[C@]13O2 |r,c:41,t:30|
Structure:
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