Target
Melanin-concentrating hormone receptor 1
Ligand
BDBM50203057
Substrate
n/a
Meas. Tech.
ChEMBL_435559 (CHEMBL903918)
Ki
19±n/a nM
Citation
 Méndez-Andino, JLColson, AOMeyers, KMMitchell, MCHodge, KHoward, JMKim, NAckley, DCHolbert, JKMittelstadt, SWDowty, MEObringer, CMSuchanek, PReizes, OHu, XEWos, JA The efficacy and cardiac evaluation of aminomethyl tetrahydronaphthalene ketopiperazines: a novel class of potent MCH-R1 antagonists. Bioorg Med Chem 15:2092-105 (2007) [PubMed]  Article 
Target
Name:
Melanin-concentrating hormone receptor 1
Synonyms:
G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45976.27
Organism:
Homo sapiens (Human)
Description:
Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:
422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
  
Inhibitor
Name:
BDBM50203057
Synonyms:
4'-fluoro-biphenyl-4-carboxylic acid [2-(4-dimethylaminomethyl-phenyl)-ethyl]-amide | CHEMBL228987
Type:
Small organic molecule
Emp. Form.:
C24H25FN2O
Mol. Mass.:
376.4665
SMILES:
CN(C)Cc1ccc(CCNC(=O)c2ccc(cc2)-c2ccc(F)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: