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Target
Stress-70 protein, mitochondrial
Ligand
BDBM50617259
Substrate
n/a
Meas. Tech.
ChEMBL_2311419
IC50
20500±n/a nM
Citation
 Ambrose, AJ; Sivinski, J; Zerio, CJ; Zhu, X; Godek, J; Kumirov, VK; Coma Brujas, T; Torra Garcia, J; Annadurai, A; Schmidlin, CJ; Werner, A; Shi, T; Zavareh, RB; Lairson, L; Zhang, DD; Chapman, E Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78. J Med Chem 66:677-694 (2023) [PubMed] 
Target
Name:
Stress-70 protein, mitochondrial
Synonyms:
75 kDa glucose-regulated protein | GRP-75 | Heat shock 70 kDa protein 9 | Mortalin | MOT | PBP74 | Peptide-binding protein 74 | Stress-70 protein, mitochondrial | GRP75_HUMAN | HSPA9 | GRP75 | HSPA9B | mt-HSP70
Type:
PROTEIN
Mol. Mass.:
73676.63
Organism:
Human
Description:
ChEMBL_118002
Residue:
679
Sequence:
MISASRAAAARLVGAAASRGPTAARHQDSWNGLSHEAFRLVSRRDYASEAIKGAVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAHGKLYSPSQIGAFVLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKSEDKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDLFGRAPSKAVNPDEAVAIGAAIQGGVLAGDVTDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISKMRELLARKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSGTGEQKEDQKEEKQ
  
Inhibitor
Name:
BDBM50617259
Synonyms:
CHEMBL5422755
Type:
Small organic molecule
Emp. Form.:
C15H17N3O2S
Mol. Mass.:
303.39
SMILES:
CC(C)[C@H](NC(=O)c1ccccc1)C(=O)Nc1nccs1 |r|
Structure:
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