Reaction Details Report a problem with these data
Target
Neurolysin, mitochondrial
Ligand
BDBM50621347
Substrate
n/a
Meas. Tech.
ChEMBL_2328158
EC50
5400±n/a nM
Citation
 Rahman, MS; Hadi Esfahani, S; Zhang, Y; Queen, A; Aljarrah, M; Kandil, H; Baez, A; Abbruscato, TJ; Karamyan, VT; Trippier, PC Imidazole Bioisostere Activators of Endopeptidase Neurolysin with Enhanced Potency and Metabolic Stability. ACS Med Chem Lett 15:510-517 (2024) [PubMed] 
Target
Name:
Neurolysin, mitochondrial
Synonyms:
3.4.24.16 | AGTBP | Angiotensin-binding protein | KIAA1226 | MEP | Microsomal endopeptidase | Mitochondrial oligopeptidase M | Neurolysin, mitochondrial | Neurotensin endopeptidase | NLN
Type:
PROTEIN
Mol. Mass.:
80651.92
Organism:
Homo sapiens
Description:
ChEMBL_121370
Residue:
704
Sequence:
MIARCLLAVRSLRRVGGSRILLRMTLGREVMSPLQAMSSYTVAGRNVLRWDLSPEQIKTRTEELIVQTKQVYDAVGMLGIEEVTYENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMSMRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDDFIDSLEKTDDDKYKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQPVAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRGLHAP
  
Inhibitor
Name:
BDBM50621347
Synonyms:
CHEMBL5085279
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: