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Target
Aldo-keto reductase family 1 member A1
Ligand
BDBM16312
Substrate
n/a
Meas. Tech.
ChEMBL_2330030
IC50
1200±n/a nM
Citation
 Zhou, HL; Hausladen, A; Anand, P; Rajavel, M; Stomberski, CT; Zhang, R; Premont, RT; Greenlee, WJ; van den Akker, F; Stamler, JS Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury. J Med Chem 66:5657-5668 (2023) [PubMed] 
Target
Name:
Aldo-keto reductase family 1 member A1
Synonyms:
Alcohol dehydrogenase [NADP+] | Aldo-keto reductase family 1 member A1 | Aldehyde Reductase (ALR1) | AK1A1_HUMAN | AKR1A1 | ALDR1 | ALR | Aldehyde reductase
Type:
Enzyme
Mol. Mass.:
36574.11
Organism:
Human
Description:
n/a
Residue:
325
Sequence:
MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY
  
Inhibitor
Name:
BDBM16312
Synonyms:
CHEMBL266497 | (4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-imidazolidine]-2',5'-dione | Sorbinil
Type:
Small organic molecule
Emp. Form.:
C11H9FN2O3
Mol. Mass.:
236.06
SMILES:
Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1 |r|
Structure:
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