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Target
Aldo-keto reductase family 1 member A1
Ligand
BDBM50621678
Substrate
n/a
Meas. Tech.
ChEMBL_2330031
IC50
48±n/a nM
Citation
 Zhou, HL; Hausladen, A; Anand, P; Rajavel, M; Stomberski, CT; Zhang, R; Premont, RT; Greenlee, WJ; van den Akker, F; Stamler, JS Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury. J Med Chem 66:5657-5668 (2023) [PubMed] 
Target
Name:
Aldo-keto reductase family 1 member A1
Synonyms:
Alcohol dehydrogenase [NADP+] | Aldo-keto reductase family 1 member A1 | Aldehyde Reductase (ALR1) | AK1A1_HUMAN | AKR1A1 | ALDR1 | ALR | Aldehyde reductase
Type:
Enzyme
Mol. Mass.:
36574.11
Organism:
Human
Description:
n/a
Residue:
325
Sequence:
MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY
  
Inhibitor
Name:
BDBM50621678
Synonyms:
CHEMBL5397238
Type:
Small organic molecule
Emp. Form.:
C17H10F2N2O5
Mol. Mass.:
360.27
SMILES:
OC(=O)Cc1c2-c3ccc(F)cc3C3(NC(=O)NC3=O)c2cc(F)c1O
Structure:
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