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Target
Alpha-2C adrenergic receptor
Ligand
BDBM50621980
Substrate
n/a
Meas. Tech.
ChEMBL_2331288
Kd
3.8±n/a nM
Citation
 Wang, X; Wang, T; Fan, X; Zhang, Z; Wang, Y; Li, Z A Molecular Toolbox of Positron Emission Tomography Tracers for General Anesthesia Mechanism Research. J Med Chem 66:6463-6497 (2023) [PubMed] 
Target
Name:
Alpha-2C adrenergic receptor
Synonyms:
Adrenergic alpha2C | Adrenergic receptor alpha | Adrenergic, alpha-2C-, receptor | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | adrenergic, alpha-2C-, receptor [Homo sapiens] | ADA2C_HUMAN | ADRA2C | ADRA2L2 | ADRA2RL2 | Adrenergic receptor
Type:
Enzyme
Mol. Mass.:
49552.32
Organism:
Human
Description:
P18825
Residue:
462
Sequence:
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
  
Inhibitor
Name:
BDBM50621980
Synonyms:
ORM-13070 C-11 | 11c-orm-13070 | Orm-13070 c-11 | (11C)ORM-13070 | 11C-ORM-13070
Type:
Small organic molecule
Emp. Form.:
C20H25N3O3
Mol. Mass.:
354.44
SMILES:
[11CH3]OCc1cccnc1N1CCN(C[C@H]2COc3ccccc3O2)CC1
Structure:
Search PDB for entries with ligand similarity: