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Target
Serine/threonine-protein kinase PLK4
Ligand
BDBM50622592
Substrate
n/a
Meas. Tech.
ChEMBL_2333454
IC50
20±n/a nM
Citation
 Sun, Y; Xue, Y; Sun, P; Mu, S; Liu, H; Sun, Y; Wang, L; Wang, J; Wu, T; Yin, W; Qin, Q; Sun, Y; Liu, N; Wang, H; Yang, H; Zhao, D; Cheng, M Discovery of the First Potent, Selective, and  J Med Chem 66:8200-8221 (2023) [PubMed] 
Target
Name:
Serine/threonine-protein kinase PLK4
Synonyms:
PLK4_HUMAN | PLK4 | SAK | STK18 | Polo-Like Kinase 4 | Serine/threonine-protein kinase PLK4
Type:
PROTEIN
Mol. Mass.:
108996.91
Organism:
Human
Description:
ChEMBL_1474078
Residue:
970
Sequence:
MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRVIQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKTYTMERCHSAEMLSVSKRSGGGENEERYSPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWFGNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQNTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMHSAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILLMFSNPTPNFH
  
Inhibitor
Name:
BDBM50622592
Synonyms:
CHEMBL5438512
Type:
Small organic molecule
Emp. Form.:
C52H65F2N11O6
Mol. Mass.:
978.16
SMILES:
Cc1cc(Nc2nc(NCc3ccc(F)cc3F)nc3n(ncc23)C2CCN(CC2)C(=O)CCCCCCCCCCCCCCCCCOc2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)n[nH]1
Structure:
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