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Target
Carbonic anhydrase 7
Ligand
BDBM10880
Substrate
n/a
Meas. Tech.
ChEMBL_2333609
Ki
2.5±n/a nM
Citation
 Nocentini, A; Bonardi, A; Bazzicalupi, C; Alterio, V; Esposito, D; Monti, SM; Smietana, M; De Simone, G; Supuran, CT; Gratteri, P; Winum, JY 6-Substituted Triazolyl Benzoxaboroles as Selective Carbonic Anhydrase Inhibitors:  J Med Chem 66:8118-8129 (2023) [PubMed] 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | Carbonate dehydratase VII | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII) | CAH7_HUMAN | CA7 | Carbonic anhydrase
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Human
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM10880
Synonyms:
Acetazolamide, AAZ | AZA2 | CHEMBL20 | Acetazolamide | N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide | Acetazolamide, AZA | AZA | Acetazolamide, 5 | Sulfonamide, 1 | Acerazolamide, AAZ | Acetazolamide, AZM | sulfonamide 1 | Acetazolamide (AAZ) | Acetazolamide (AZM) | AZM acetazolamide | Acetazolamide (AZA) | US10172837, Acetazolamide | US11278534, Example acetazolamide | US11535599, Example acetazolamide
Type:
Small organic molecule
Emp. Form.:
C4H6N4O3S2
Mol. Mass.:
221.99
SMILES:
CC(=O)Nc1nnc(s1)S(=O)(=O)N
Structure:
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