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Target
Dual specificity protein kinase CLK1
Ligand
BDBM50623175
Substrate
n/a
Meas. Tech.
ChEMBL_2336763
Ki
51±n/a nM
Citation
 El-Gamil, DS; ElHady, AK; Chen, PJ; Hwang, TL; Abadi, AH; Abdel-Halim, M; Engel, M Discovery of novel 5-methoxybenzothiophene hydrazides as metabolically stable Clk1 inhibitors with high potency and unprecedented Clk1 isoenzyme selectivity. Eur J Med Chem 247:0 (2023) [PubMed] 
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC2-like kinase 1 (CLK1) | CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1 | CLK1_HUMAN | CLK1 | CLK
Type:
Protein
Mol. Mass.:
57322.21
Organism:
Human
Description:
P49759
Residue:
484
Sequence:
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
  
Inhibitor
Name:
BDBM50623175
Synonyms:
CHEMBL5424844
Type:
Small organic molecule
Emp. Form.:
C16H12Cl2N2O2S
Mol. Mass.:
367.26
SMILES:
COc1ccc2sc(cc2c1)C(=O)NNc1cc(Cl)cc(Cl)c1
Structure:
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