Reaction Details Report a problem with these data
Target
4-hydroxy-tetrahydrodipicolinate synthase 1, chloroplastic
Ligand
BDBM50625573
Substrate
n/a
Meas. Tech.
ChEMBL_2346406
IC50
35600±n/a nM
Citation
 Christoff, RM; Al Bayer, M; Soares da Costa, TP; Perugini, MA; Abbott, BM Enhancing allosteric inhibition of dihydrodipicolinate synthase through the design and synthesis of novel dimeric compounds. RSC Med Chem 14:1698-1703 (2023) [PubMed] 
Target
Name:
4-hydroxy-tetrahydrodipicolinate synthase 1, chloroplastic
Synonyms:
4-hydroxy-tetrahydrodipicolinate synthase 1, chloroplastic | 4.3.3.7 | DHDPS | DHDPS1 | DHPS1 | HTPA synthase 1
Type:
PROTEIN
Mol. Mass.:
40624.00
Organism:
Arabidopsis thaliana
Description:
ChEMBL_121379
Residue:
365
Sequence:
MSALKNYGLISIDSALHFPRSNQLQSYKRRNAKWVSPIAAVVPNFHLPMRSLEDKNRTNTDDIRSLRVITAIKTPYLPDGRFDLQAYDDLVNTQIENGAEGVIVGGTTGEGQLMSWDEHIMLIGHTVNCFGGRIKVIGNTGSNSTREAIHATEQGFAMGMHGALHINPYYGKTSIEGMNAHFQTVLHMGPTIIYNVPGRTCQDIPPQVIFKLSQNPNMAGVKECVGNNRVEEYTEKGIVVWSGNDDQCHDSRWDHGATGVISVTSNLVPGLMRKLMFEGRNSALNAKLLPLMDWLFQEPNPIGVNTALAQLGVARPVFRLPYVPLPLSKRIEFVKLVKEIGREHFVGDRDVQVLDDDDFILIGRY
  
Inhibitor
Name:
BDBM50625573
Synonyms:
CHEMBL5437863
Type:
Small organic molecule
Emp. Form.:
C27H22N2O10S2
Mol. Mass.:
598.61
SMILES:
COc1ccc(\C=C2/SC(=O)N([C@H](C[C@H](N3C(=O)S\C(=C/c4ccc(OC)cc4)C3=O)C(O)=O)C(O)=O)C2=O)cc1 |r|
Structure:
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