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Target
Macrophage-expressed gene 1 protein
Ligand
BDBM50081539
Substrate
n/a
Meas. Tech.
ChEMBL_2347446
IC50
9.0±n/a nM
Citation
 Zeng, Y; Ren, X; Jin, P; Zhang, Y; Zhuo, M; Wang, J Development of MPS1 Inhibitors: Recent Advances and Perspectives. J Med Chem 66:16484-16514 (2023) [PubMed] 
Target
Name:
Macrophage-expressed gene 1 protein
Synonyms:
Macrophage gene 1 protein | Macrophage-expressed gene 1 protein | Macrophage-expressed gene 1 protein, processed form | Mpeg1 | mPFN2 | Mpg-1 | P-2 | Perforin-2 | PFN2 | Protein MPS1
Type:
PROTEIN
Mol. Mass.:
78384.58
Organism:
Mus musculus
Description:
ChEMBL_121280
Residue:
713
Sequence:
MNSFMALVLIWMIIACAEADKPLGETGTTGFQICKNALKLPVLEVLPGGGWDNLRNVDMGRVMDLTYTNCKTTEDGQYIIPDEVYTIPQKESNLEMNSEVLESWMNYQSTTSLSINTELALFSRVNGKFSTEFQRMKTLQVKDQAVTTRVQVRNRIYTVKTTPTSELSLGFTKALMDICDQLEKNQTKMATYLAELLILNYGTHVITSVDAGAALVQEDHVRSSFLLDNQNSQNTVTASAGIAFLNIVNFKVETDYISQTSLTKDYLSNRTNSRVQSFGGVPFYPGITLETWQKGITNHLVAIDRAGLPLHFFIKPDKLPGLPGPLVKKLSKTVETAVRHYYTFNTHPGCTNVDSPNFNFQANMDDDSCDAKVTNFTFGGVYQECTELSGDVLCQNLEQKNLLTGDFSCPPGYSPVHLLSQTHEEGYSRLECKKKCTLKIFCKTVCEDVFRVAKAEFRAYWCVAAGQVPDNSGLLFGGVFTDKTINPMTNAQSCPAGYIPLNLFESLKVCVSLDYELGFKFSVPFGGFFSCIMGNPLVNSDTAKDVRAPSLKKCPGGFSQHLAVISDGCQVSYCVKAGIFTGGSLLPVRLPPYTKPPLMSQVATNTVIVTNSETARSWIKDPQTNQWKLGEPLELRRAMTVIHGDSNGMSGGEAAGITLGVTIALGIVITLAIYGTRKYKKKEYQEIEEQESLVGSLATDATVLNGEEDPSPA
  
Inhibitor
Name:
BDBM50081539
Synonyms:
CHEMBL3422104
Type:
Small organic molecule
Emp. Form.:
C29H28N6O
Mol. Mass.:
476.23
SMILES:
CC(C)CNc1nc(cn2c(cnc12)-c1ccc(cc1)C(=O)NC1CC1)-c1cccc2ncccc12
Structure:
Search PDB for entries with ligand similarity: