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Target
Ceramide glucosyltransferase
Ligand
BDBM50625986
Substrate
n/a
Meas. Tech.
ChEMBL_2348349
IC50
7.3±n/a nM
Citation
 Loughran, HM; Schirripa, KM; Roecker, AJ; Breslin, MJ; Tong, L; Fillgrove, KL; Kuo, Y; Bleasby, K; Collier, H; Altman, MD; Ford, MC; Newman, JA; Drolet, RE; Cosden, M; Jinn, S; Flick, RB; Liu, X; Minnick, C; Watt, ML; Lemaire, W; Burlein, C; Adam, GC; Austin, LA; Marcus, JN; Smith, SM; Fraley, ME Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections. ACS Med Chem Lett 15:123-131 (2024) [PubMed] 
Target
Name:
Ceramide glucosyltransferase
Synonyms:
GCS | GLCT-1 | Glucosylceramide synthase | UDP-glucose ceramide glucosyltransferase | UDP-glucose:N-acylsphingosine D-glucosyltransferase | CEGT_HUMAN | UGCG
Type:
PROTEIN
Mol. Mass.:
44859.25
Organism:
Human
Description:
ChEMBL_1435474
Residue:
394
Sequence:
MALLDLALEGMAVFGFVLFLVLWLMHFMAIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIDVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPGYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTEKVGLVHGLPYVADRQGFAATLEQVYFGTSHPRYYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWRFAMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRTGRYRLRCGGTAEEILDV
  
Inhibitor
Name:
BDBM50625986
Synonyms:
CHEMBL5395985
Type:
Small organic molecule
Emp. Form.:
C22H19F5N2O3
Mol. Mass.:
454.40
SMILES:
CN1Cc2cc(ccc2C1=O)-c1c2C(=O)N(Cc2cc(F)c1F)[C@@H](C(C)(C)O)C(F)(F)F |r|
Structure:
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