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Target
Poly [ADP-ribose] polymerase 1
Ligand
BDBM50626157
Substrate
n/a
Meas. Tech.
ChEMBL_2349356
IC50
5.0±n/a nM
Citation
 Sabnis, RW Novel PARP1 Inhibitors for Treating Cancer. ACS Med Chem Lett 15:161-162 (2024) [PubMed] 
Target
Name:
Poly [ADP-ribose] polymerase 1
Synonyms:
PARP1_HUMAN | Poly [ADP-ribose] polymerase-1 | Poly(ADP-ribose) polymerase-1 (ARTD1/PARP1) | NT-PARP-1 | Poly(ADP-ribose) polymerase 1 (PARP1) | ARTD1 | Poly [ADP-ribose] polymerase 1, 24-kDa form | Poly [ADP-ribose] polymerase 1, processed C-terminus | Poly [ADP-ribose] polymerase 1 (PARP1) | 2.4.2.- | DNA ADP-ribosyltransferase PARP1 | Poly[ADP-ribose] synthase 1 | Poly [ADP-ribose] polymerase 1, 89-kDa form | Poly [ADP-ribose] polymerase 1, 28-kDa form | PARP1 | (ARTD1 or PARP1) | Poly [ADP-ribose] polymerase 1, processed N-terminus | ADPRT 1 | PARP-1 | NAD(+) ADP-ribosyltransferase 1 | Protein poly-ADP-ribosyltransferase PARP1 | Poly [ADP-ribose] polymerase (PARP) | PPOL | ADP-ribosyltransferase diphtheria toxin-like 1 | 2.4.2.30 | ADPRT | Poly [ADP-ribose] polymerase 1 (PARP-1) | Synonyms=ADPRT | Human diphtheria toxin-like ADP-ribosyltransferase (ARTD1 or PARP1) | Poly [ADP-ribose] polymerase 1 (PARP)
Type:
Mol. Mass.:
113114.22
Organism:
Human
Description:
P09874
Residue:
1014
Sequence:
MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW
  
Inhibitor
Name:
BDBM50626157
Synonyms:
CHEMBL5404994
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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