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Target
Transcriptional enhancer factor TEF-3/Transcriptional coactivator YAP1
Ligand
BDBM50626283
Substrate
n/a
Meas. Tech.
ChEMBL_2349718
IC50
<2.0±n/a nM
Citation
 Lou, J; Lu, Y; Cheng, J; Zhou, F; Yan, Z; Zhang, D; Meng, X; Zhao, Y A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities. Eur J Med Chem 243:0 (2022) [PubMed] 
Target
Name:
Transcriptional enhancer factor TEF-3/Transcriptional coactivator YAP1
Synonyms:
n/a
Type:
n/a
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 0 components.
Component 1
Name:
Transcriptional enhancer factor TEF-3
Synonyms:
TEA domain family member 4 | TEAD-4 | Transcriptional enhancer factor TEF-3 | Transcription factor 13-like 1 | Transcription factor RTEF-1 | TEAD4_HUMAN | TEAD4 | RTEF1 | TCF13L1 | TEF3
Type:
PROTEIN
Mol. Mass.:
48333.01
Organism:
Human
Description:
ChEMBL_118073
Residue:
434
Sequence:
MEGTAGTITSNEWSSPTSPEGSTASGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKDKALQSMAAMSSAQIISATAFHSSMALARGPGRPAVSGFWQGALPGQAGTSHDVKPFSQQTYAVQPPLPLPGFESPAGPAPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE
  
Component 2
Name:
Transcriptional coactivator YAP1
Synonyms:
Protein yorkie homolog | YAP1 | YAP65 | Yes-associated protein 1 | Yes-associated protein YAP65 homolog
Type:
PROTEIN
Mol. Mass.:
54449.34
Organism:
Homo sapiens
Description:
ChEMBL_121507
Residue:
504
Sequence:
MDPGQQPPPQPAPQGQGQPPSQPPQGQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATPTAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFAMNQRISQSAPVKQPPPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNPVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL
  
Inhibitor
Name:
BDBM50626283
Synonyms:
US12083101, Example 106 | CHEMBL5400107
Type:
Small organic molecule
Emp. Form.:
C26H25ClF2N2O4
Mol. Mass.:
502.95
SMILES:
COCCOc1ccc(C(N)=O)c(-c2c(Cl)c(F)cc3c2[C@H](C)[C@@](CN)(c2ccccc2)O3)c1F
Structure:
Search PDB for entries with ligand similarity: