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Target
DDB1- and CUL4-associated factor 15
Ligand
BDBM50627138
Substrate
n/a
Meas. Tech.
ChEMBL_2352569
Kd
47±n/a nM
Citation
 Vulpetti, A; Holzer, P; Schmiedeberg, N; Imbach-Weese, P; Pissot-Soldermann, C; Hollingworth, GJ; Radimerski, T; Thoma, CR; Stachyra, TM; Wojtynek, M; Maschlej, M; Chau, S; Schuffenhauer, A; Fernández, C; Schröder, M; Renatus, M Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field. ACS Med Chem Lett 14:949-954 (2023) [PubMed] 
Target
Name:
DDB1- and CUL4-associated factor 15
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
66463.23
Organism:
Human
Description:
Q66K64
Residue:
600
Sequence:
MAPSSKSERNSGAGSGGGGPGGAGGKRAAGRRREHVLKQLERVKISGQLSPRLFRKLPPRVCVSLKNIVDEDFLYAGHIFLGFSKCGRYVLSYTSSSGDDDFSFYIYHLYWWEFNVHSKLKLVRQVRLFQDEEIYSDLYLTVCEWPSDASKVIVFGFNTRSANGMLMNMMMMSDENHRDIYVSTVAVPPPGRCAACQDASRAHPGDPNAQCLRHGFMLHTKYQVVYPFPTFQPAFQLKKDQVVLLNTSYSLVACAVSVHSAGDRSFCQILYDHSTCPLAPASPPEPQSPELPPALPSFCPEAAPARSSGSPEPSPAIAKAKEFVADIFRRAKEAKGGVPEEARPALCPGPSGSRCRAHSEPLALCGETAPRDSPPASEAPASEPGYVNYTKLYYVLESGEGTEPEDELEDDKISLPFVVTDLRGRNLRPMRERTAVQGQYLTVEQLTLDFEYVINEVIRHDATWGHQFCSFSDYDIVILEVCPETNQVLINIGLLLLAFPSPTEEGQLRPKTYHTSLKVAWDLNTGIFETVSVGDLTEVKGQTSGSVWSSYRKSCVDMVMKWLVPESSGRYVNRMTNEALHKGCSLKVLADSERYTWIVL
  
Inhibitor
Name:
BDBM50627138
Synonyms:
CHEMBL5397181
Type:
Small organic molecule
Emp. Form.:
C27H33ClN6O
Mol. Mass.:
493.06
SMILES:
CC(=O)N1CCN(CC1)c2ccc3c(c2)nc(nc3NCCN)C4(CCCC4)c5ccc(cc5)Cl
Structure:
Search PDB for entries with ligand similarity: