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Target
Polycomb protein EED
Ligand
BDBM50627141
Substrate
n/a
Meas. Tech.
ChEMBL_2352572
Kd
21000±n/a nM
Citation
 Vulpetti, A; Holzer, P; Schmiedeberg, N; Imbach-Weese, P; Pissot-Soldermann, C; Hollingworth, GJ; Radimerski, T; Thoma, CR; Stachyra, TM; Wojtynek, M; Maschlej, M; Chau, S; Schuffenhauer, A; Fernández, C; Schröder, M; Renatus, M Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field. ACS Med Chem Lett 14:949-954 (2023) [PubMed] 
Target
Name:
Polycomb protein EED
Synonyms:
EED_HUMAN | EED | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED
Type:
Protein
Mol. Mass.:
50201.68
Organism:
Human
Description:
O75530
Residue:
441
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
  
Inhibitor
Name:
BDBM50627141
Synonyms:
CHEMBL5403546
Type:
Small organic molecule
Emp. Form.:
C21H22N2
Mol. Mass.:
302.42
SMILES:
CC(C)(Cc1ccccc1)C1=Cc2ccccc2C2=NCCN12 |t:11,20|
Structure:
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