Reaction Details Report a problem with these data
Target
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Ligand
BDBM50628841
Substrate
n/a
Meas. Tech.
ChEMBL_2356950
IC50
0.300000±n/a nM
Citation
 Li, Y; Liu, Y; Zhang, Y; Wu, Y; Xing, Z; Wang, J; Fan, GH Discovery of a First-in-Class CD38 Inhibitor for the Treatment of Mitochondrial Myopathy. J Med Chem 66:12762-12775 (2023) [PubMed] 
Target
Name:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Synonyms:
CD38_HUMAN | CD38 | Lymphocyte differentiation antigen CD38
Type:
PROTEIN
Mol. Mass.:
34333.62
Organism:
Human
Description:
ChEMBL_1509931
Residue:
300
Sequence:
MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFPETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCNKILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDCSNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEAWVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
  
Inhibitor
Name:
BDBM50628841
Synonyms:
CHEMBL5410644
Type:
Small organic molecule
Emp. Form.:
C14H10FN5O
Mol. Mass.:
283.27
SMILES:
Fc1cccc(NC(=O)c2ccnc(n2)-n2ccnc2)c1
Structure:
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