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Target
Carnitine O-palmitoyltransferase 1, liver isoform
Ligand
BDBM50403044
Substrate
n/a
Meas. Tech.
ChEMBL_2364914
EC50
3000±n/a nM
Citation
 Dow, LF; Case, AM; Paustian, MP; Pinkerton, BR; Simeon, P; Trippier, PC The evolution of small molecule enzyme activators. RSC Med Chem 14:2206-2230 (2023) [PubMed] 
Target
Name:
Carnitine O-palmitoyltransferase 1, liver isoform
Synonyms:
CPT I | CPT1-L | CPTI-L | Carnitine O-palmitoyltransferase I, liver isoform | CPT1A_HUMAN | CPT1A | CPT1
Type:
PROTEIN
Mol. Mass.:
88389.31
Organism:
Human
Description:
ChEMBL_887463
Residue:
773
Sequence:
MAEAHQAVAFQFTVTPDGIDLRLSHEALRQIYLSGLHSWKKKFIRFKNGIITGVYPASPSSWLIVVVGVMTTMYAKIDPSLGIIAKINRTLETANCMSSQTKNVVSGVLFGTGLWVALIVTMRYSLKVLLSYHGWMFTEHGKMSRATKIWMGMVKIFSGRKPMLYSFQTSLPRLPVPAVKDTVNRYLQSVRPLMKEEDFKRMTALAQDFAVGLGPRLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMDLLYILPTHIQAARAGNAIHAILLYRRKLDREEIKPIRLLGSTIPLCSAQWERMFNTSRIPGEETDTIQHMRDSKHIVVYHRGRYFKVWLYHDGRLLKPREMEQQMQRILDNTSEPQPGEARLAALTAGDRVPWARCRQAYFGRGKNKQSLDAVEKAAFFVTLDETEEGYRSEDPDTSMDSYAKSLLHGRCYDRWFDKSFTFVVFKNGKMGLNAEHSWADAPIVAHLWEYVMSIDSLQLGYAEDGHCKGDINPNIPYPTRLQWDIPGECQEVIETSLNTANLLANDVDFHSFPFVAFGKGIIKKCRTSPDAFVQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCDFVRAMVDPAQTVEQRLKLFKLASEKHQHMYRLAMTGSGIDRHLFCLYVVSKYLAVESPFLKEVLSEPWRLSTSQTPQQQVELFDLENNPEYVSSGGGFGPVADDGYGVSYILVGENLINFHISSKFSCPETDSHRFGRHLKEAMTDIITLFGLSSNSKK
  
Inhibitor
Name:
BDBM50403044
Synonyms:
CHEMBL179241
Type:
Small organic molecule
Emp. Form.:
C19 H30 O2 S
Mol. Mass.:
n/a
SMILES:
CCCCCCCC[C@@]1(C)SC(=O)C(CC=C)(CC=C)C1=O
Structure:
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