Reaction Details Report a problem with these data
Target
N-glycosylase/DNA lyase
Ligand
BDBM50630978
Substrate
n/a
Meas. Tech.
ChEMBL_2364947
EC50
4100±n/a nM
Citation
 Dow, LF; Case, AM; Paustian, MP; Pinkerton, BR; Simeon, P; Trippier, PC The evolution of small molecule enzyme activators. RSC Med Chem 14:2206-2230 (2023) [PubMed] 
Target
Name:
N-glycosylase/DNA lyase
Synonyms:
8-Oxoguanine DNA glycosylase-1 (OGG1) | OGG1_HUMAN | OGG1 | MMH | MUTM | OGH1
Type:
Protein
Mol. Mass.:
38794.33
Organism:
Human
Description:
O15527
Residue:
345
Sequence:
MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
  
Inhibitor
Name:
BDBM50630978
Synonyms:
CHEMBL5402302
Type:
Small organic molecule
Emp. Form.:
C20H21N5O
Mol. Mass.:
347.42
SMILES:
C[C@H](Nc1cc(C)nc(Nc2ccccc2)n1)C(=O)Nc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: