Reaction Details Report a problem with these data
Target
Probable ATP-dependent RNA helicase DDX5
Ligand
BDBM50036133
Substrate
n/a
Meas. Tech.
ChEMBL_2367915
Kd
34±n/a nM
Citation
 Cui, Q; Huang, C; Liu, JY; Zhang, JT Small Molecule Inhibitors Targeting the "Undruggable" Survivin: The Past, Present, and Future from a Medicinal Chemist's Perspective. J Med Chem 66:16515-16545 (2023) [PubMed] 
Target
Name:
Probable ATP-dependent RNA helicase DDX5
Synonyms:
3.6.4.13 | DDX5 | DEAD box protein 5 | G17P1 | HELR | HLR1 | Probable ATP-dependent RNA helicase DDX5 | RNA helicase p68
Type:
PROTEIN
Mol. Mass.:
69164.93
Organism:
Homo sapiens
Description:
ChEMBL_117967
Residue:
614
Sequence:
MSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVETKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYIHRIGRTARSTKTGTAYTFFTPNNIKQVSDLISVLREANQAINPKLLQLVEDRGSGRSRGRGGMKDDRRDRYSAGKRGGFNTFRDRENYDRGYSSLLKRDFGAKTQNGVYSAANYTNGSFGSNFVSAGIQTSFRTGNPTGTYQNGYDSTQQYGSNVPNMHNGMNQQAYAYPATAAAPMIGYPMPTGYSQ
  
Inhibitor
Name:
BDBM50036133
Synonyms:
7-ethyl-7-hydroxy-(7S)-7,8,11,13-tetrahydro-10H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11-dione | 7-ethyl-7-hydroxy-(7S)-7,8,11,13-tetrahydro-10H-[1,3]dioxolo[5,4-g]pyrano[3'',4'':6,7]indolizino[1,2-b]quinoline-8,11-dione | CHEMBL307794
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: