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Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM50633254
Substrate
n/a
Meas. Tech.
ChEMBL_2375555
IC50
2900±n/a nM
Citation
 Paz, JD; Denise de Moura Sperotto, N; Ramos, AS; Pissinate, K; da Silva Rodrigues Junior, V; Abbadi, BL; Borsoi, AF; Rambo, RS; Corso Minotto, AC; da Silva Dadda, A; Galina, L; Macchi Hopf, FS; Muniz, MN; Borges Martinelli, LK; Roth, CD; Madeira Silva, RB; Perelló, MA; de Matos Czeczot, A; Neves, CE; Duarte, LS; Leyser, M; Dias de Oliveira, S; Bizarro, CV; Machado, P; Basso, LA Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation. Eur J Med Chem 245:0 (2023) [PubMed] 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
Enoyl-[acyl-carrier-protein] reductase | NADH-dependent enoyl-ACP reductase | INHA_MYCTU | inhA | Enoyl-[acyl-carrier-protein] reductase [NADH] | Enoyl-ACP Reductase (InhA)
Type:
Enzyme
Mol. Mass.:
28526.00
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
P9WGR1
Residue:
269
Sequence:
MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL
  
Inhibitor
Name:
BDBM50633254
Synonyms:
CHEMBL5399436
Type:
Small organic molecule
Emp. Form.:
C22H24ClN3
Mol. Mass.:
365.91
SMILES:
CCc1cc(Nc2ccc(cc2)N2CCCCC2)c2cc(Cl)ccc2n1
Structure:
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