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Target
Signal transducer and activator of transcription 3
Ligand
BDBM50366597
Substrate
n/a
Meas. Tech.
ChEMBL_2424083
IC50
1209±n/a nM
Citation
 Zhang, L; Liu, P; Jiang, Y; Fan, D; He, X; Zhang, J; Luo, B; Sui, J; Luo, Y; Fu, X; Yang, T Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level. Eur J Med Chem 272:0[PubMed] 
Target
Name:
Signal transducer and activator of transcription 3
Synonyms:
Signal transducer and activator of transcription 3 | Signal transducer and activator of transcription 3 (STAT3) | STAT3_HUMAN | STAT3 | APRF
Type:
Protein
Mol. Mass.:
88064.31
Organism:
Human
Description:
P40763
Residue:
770
Sequence:
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
  
Inhibitor
Name:
BDBM50366597
Synonyms:
2-Acetylfuranonaphthoquinone | BBI-608 | Napabucasin
Type:
Small organic molecule
Emp. Form.:
C14H8O4
Mol. Mass.:
240.21
SMILES:
CC(=O)c1cc2c(o1)C(=O)c3ccccc3C2=O
Structure:
Search PDB for entries with ligand similarity: