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Target
Programmed cell death 1 ligand 1
Ligand
BDBM50239947
Substrate
n/a
Meas. Tech.
ChEMBL_2425914
IC50
18±n/a nM
Citation
 Zhang, H; Zhang, Y; Feng, Z; Shuai, M; Ma, X; Wang, S; Yu, S; Deng, R; Luo, D; Shi, J; Pu, C; Li, R Discovery of Novel Proteolysis-Targeting Chimera Molecules as Degraders of Programmed Cell Death-Ligand 1 for Breast Cancer Therapy. J Med Chem 67:10589-10600[PubMed] 
Target
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | CD_antigen=CD274 | PD-L1 | PDCD1 ligand 1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1 | PD1L1_HUMAN | CD274 | B7H1 | PDCD1L1 | PDCD1LG1 | PDL1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Human
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM50239947
Synonyms:
US9872852, Example 202 | CHEMBL4089730 | US20230303494, Compound BMS202 | US20240043392, Compound BMS-202 | US20240327387, Compound BMS202
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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