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Target
Retinal dehydrogenase 2
Ligand
BDBM50459608
Substrate
n/a
Meas. Tech.
ChEMBL_2436667
Ki
4.2±n/a nM
Citation
 Hillebrand, L; Liang, XJ; Serafim, RAM; Gehringer, M Emerging and Re-emerging Warheads for Targeted Covalent Inhibitors: An Update. J Med Chem 67:7668-7758[PubMed] 
Target
Name:
Retinal dehydrogenase 2
Synonyms:
Aldehyde dehydrogenase family 1 member A2 | RALDH 2 | RALDH(II) | Retinal dehydrogenase 2 | Retinaldehyde-specific dehydrogenase type 2 | AL1A2_HUMAN | ALDH1A2 | RALDH2
Type:
PROTEIN
Mol. Mass.:
56720.77
Organism:
Human
Description:
ChEMBL_109700
Residue:
518
Sequence:
MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
  
Inhibitor
Name:
BDBM50459608
Synonyms:
CHEMBL3276621 | CHEBI:90441
Type:
Small organic molecule
Emp. Form.:
C12H20Cl4N2O2
Mol. Mass.:
366.12
SMILES:
C(CCCCNC(=O)C(Cl)Cl)CCCNC(=O)C(Cl)Cl
Structure:
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