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Target
Thymic stromal lymphopoietin
Ligand
BDBM50643100
Substrate
n/a
Meas. Tech.
ChEMBL_2459990
Kd
4.0±n/a nM
Citation
 Narjes, F; Edfeldt, F; Petersen, J; Öster, L; Hamblet, C; Bird, J; Bold, P; Rae, R; Bäck, E; Stomilovic, S; Zlatoidsky, P; Svensson, T; Hidestål, L; Kunalingam, L; Shamovsky, I; De Maria, L; Gordon, E; Lewis, RJ; Watcham, S; van Rietschoten, K; Mudd, GE; Harrison, H; Chen, L; Skynner, MJ Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin. J Med Chem 67:2220-2235[PubMed] 
Target
Name:
Thymic stromal lymphopoietin
Synonyms:
Thymic stromal lymphopoietin | TSLP
Type:
PROTEIN
Mol. Mass.:
18154.72
Organism:
Homo sapiens
Description:
ChEMBL_114892
Residue:
159
Sequence:
MFPFALLYVLSVSFRKIFILQLVGLVLTYDFTNCDFEKIKAAYLSTISKDLITYMSGTKSTEFNNTVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSETQINATQAMKKRRKRKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ
  
Inhibitor
Name:
BDBM50643100
Synonyms:
CHEMBL5566614
Type:
Small organic molecule
Emp. Form.:
C82H108ClFN22O21S3
Mol. Mass.:
1888.55
SMILES:
CC(=O)N[C@H]1CSCCC(=O)N2CN3CN(C2)C(=O)CCSC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]c4ccccc24)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc1ccc(F)c(Cl)c1)C(=O)N[C@H](C(N)=O)CSCCC3=O
Structure:
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