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Target
Caspase-1
Ligand
BDBM50200553
Substrate
n/a
Meas. Tech.
ChEMBL_2460905
Ki
48±n/a nM
Citation
 Modi, P; Shah, BM; Patel, S Interleukin-1β converting enzyme (ICE): A comprehensive review on discovery and development of caspase-1 inhibitors. Eur J Med Chem 261:0[PubMed] 
Target
Name:
Caspase-1
Synonyms:
Caspase | Interleukin-1 beta-converting enzyme | Caspase 1 | Interleukin-1 beta convertase | ICE | CASP1_HUMAN | CASP1 | IL1BC | IL1BCE
Type:
Enzyme
Mol. Mass.:
45154.13
Organism:
Human
Description:
P29466
Residue:
404
Sequence:
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
  
Inhibitor
Name:
BDBM50200553
Synonyms:
CHEMBL3898379
Type:
Small organic molecule
Emp. Form.:
C30H44N6O2
Mol. Mass.:
520.35
SMILES:
CC1Oc2c(C)c(C)c(O)c(C)c2CC1CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1
Structure:
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