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Target
Fibroblast growth factor receptor 3
Ligand
BDBM50644197
Substrate
n/a
Meas. Tech.
ChEMBL_2465460
EC50
1776±n/a nM
Citation
 Schwarz, M; Kurkunov, M; Wittlinger, F; Rudalska, R; Wang, G; Schwalm, MP; Rasch, A; Wagner, B; Laufer, SA; Knapp, S; Dauch, D; Gehringer, M Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on SNAr Electrophiles. J Med Chem 67:6549-6569[PubMed] 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
FGFR3_HUMAN | FGFR3 | JTK4 | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | CD_antigen: CD333 | FGFR-3
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Human
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM50644197
Synonyms:
CHEMBL5575075
Type:
Small organic molecule
Emp. Form.:
C21H15Cl2N5O4
Mol. Mass.:
472.29
SMILES:
COc1cc(OC)c(Cl)c(-c2ccc3nc(Nc4ncccc4[N+](=O)[O-])ncc3c2)c1Cl
Structure:
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