Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3
Ligand
BDBM50233461
Substrate
n/a
Meas. Tech.
ChEMBL_2465460
EC50
2236±n/a nM
Citation
 Schwarz, M; Kurkunov, M; Wittlinger, F; Rudalska, R; Wang, G; Schwalm, MP; Rasch, A; Wagner, B; Laufer, SA; Knapp, S; Dauch, D; Gehringer, M Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on SNAr Electrophiles. J Med Chem 67:6549-6569[PubMed] 
Target
Name:
Fibroblast growth factor receptor 3
Synonyms:
FGFR3_HUMAN | FGFR3 | JTK4 | Fibroblast growth factor receptor | Fibroblast growth factor receptor 3 (FGFR3) | CD_antigen: CD333 | FGFR-3
Type:
Protein
Mol. Mass.:
87699.57
Organism:
Human
Description:
P22607
Residue:
806
Sequence:
MGAPACALALCVAVAIVAGASSESLGTEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTGLVPSERVLVGPQRLQVLNASHEDSGAYSCRQRLTQRVLCHFSVRVTDAPSSGDDEDGEDEAEDTGVDTGAPYWTRPERMDKKLLAVPAANTVRFRCPAAGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTVLKTAGANTTDKELEVLSLHNVTFEDAGEYTCLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM50233461
Synonyms:
CHEMBL4068896
Type:
Small organic molecule
Emp. Form.:
C26H22Cl2N4O3
Mol. Mass.:
508.11
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(Nc3c(C)cccc3NC(=O)C=C)ncc2c1
Structure:
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