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Target
Excitatory amino acid transporter 1
Ligand
BDBM50644332
Substrate
n/a
Meas. Tech.
ChEMBL_2465786
EC50
2.2±n/a nM
Citation
 Fontana, ACK; Poli, ANR; Gour, J; Srikanth, YVV; Anastasi, N; Ashok, D; Khatiwada, A; Reeb, KL; Cheng, MH; Bahar, I; Rawls, SM; Salvino, JM Synthesis and Structure-Activity Relationships for Glutamate Transporter Allosteric Modulators. J Med Chem 67:6119-6143[PubMed] 
Target
Name:
Excitatory amino acid transporter 1
Synonyms:
Excitatory Amino Acid EAAT1 | EAA1_HUMAN | SLC1A3 | EAAT1 | GLAST | GLAST1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59577.19
Organism:
Human
Description:
Excitatory Amino Acid EAAT1 0 HUMAN::P43003
Residue:
542
Sequence:
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVGTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPPNLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSETKM
  
Inhibitor
Name:
BDBM50644332
Synonyms:
CHEMBL5571181
Type:
Small organic molecule
Emp. Form.:
C19H23N7
Mol. Mass.:
349.44
SMILES:
CN1CCN(C(c2ccncc2)c2nnnn2Cc2ccccc2)CC1
Structure:
Search PDB for entries with ligand similarity: