Reaction Details Report a problem with these data
Target
Excitatory amino acid transporter 2
Ligand
BDBM50644342
Substrate
n/a
Meas. Tech.
ChEMBL_2465787
EC50
0.890000±n/a nM
Citation
 Fontana, ACK; Poli, ANR; Gour, J; Srikanth, YVV; Anastasi, N; Ashok, D; Khatiwada, A; Reeb, KL; Cheng, MH; Bahar, I; Rawls, SM; Salvino, JM Synthesis and Structure-Activity Relationships for Glutamate Transporter Allosteric Modulators. J Med Chem 67:6119-6143[PubMed] 
Target
Name:
Excitatory amino acid transporter 2
Synonyms:
Solute carrier family 1 member 2 | Glutamate/aspartate transporter II | Sodium-dependent glutamate/aspartate transporter 2 | EAA2_HUMAN | SLC1A2 | EAAT2 | GLT1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
62103.57
Organism:
Human
Description:
Excitatory Amino Acid EAAT2 0 0::P43004
Residue:
574
Sequence:
MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVCGGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVLDGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYAAHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
  
Inhibitor
Name:
BDBM50644342
Synonyms:
CHEMBL5565003
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: