Reaction Details Report a problem with these data
Target
Eukaryotic elongation factor 2 kinase
Ligand
BDBM50646955
Substrate
n/a
Meas. Tech.
ChEMBL_2478328
Kd
436±n/a nM
Citation
 Zhao, X; Zhong, C; Zhu, R; Gong, R; Liu, B; He, L; Tian, S; Jin, J; Jiang, T; Chen, JL; Wan, X; Liu, W; Jiang, S; Deng, P; Cheng, Y; Ye, N Structure-Activity Relationship Studies of Substituted 2-Phenyl-1,2,4-triazine-3,5(2H,4H)-dione Analogues: Development of Potent eEF2K Degraders against Triple-Negative Breast Cancer. J Med Chem 67:15837-15861[PubMed] 
Target
Name:
Eukaryotic elongation factor 2 kinase
Synonyms:
Eukaryotic elongation factor 2 kinase (EEF2K) | Eukaryotic elongation factor 2 kinase (eEF-2K) | eEF-2 kinase | eEF-2K | Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EF2K_HUMAN | EEF2K | Serine/threonine-protein kinase EEF2K
Type:
Protein
Mol. Mass.:
82116.99
Organism:
Human
Description:
n/a
Residue:
725
Sequence:
MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYYSNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPQVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDNMASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGRVCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFCEKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQDEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQMEE
  
Inhibitor
Name:
BDBM50646955
Synonyms:
CHEMBL5590973
Type:
Small organic molecule
Emp. Form.:
C30H36FN5O5
Mol. Mass.:
565.65
SMILES:
Cc1ccc(-n2nc(C(=O)N3CCCC(CNC(=O)OC(C)(C)C)C3)c(=O)n(Cc3cccc(F)c3)c2=O)cc1C
Structure:
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