Target
Urokinase-type plasminogen activator
Ligand
BDBM50147422
Substrate
n/a
Meas. Tech.
ChEMBL_460612 (CHEMBL927669)
IC50
37±n/a nM
Citation
 Frederickson, MCallaghan, OChessari, GCongreve, MCowan, SRMatthews, JEMcMenamin, RSmith, DMVinkovic, MWallis, NG Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator. J Med Chem 51:183-6 (2008) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
Urokinase-type plasminogen activator short chain A | U-plasminogen activator | UROK_HUMAN | Urokinase-type plasminogen activator/surface receptor | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator long chain A | 3.4.21.73 | Urokinase-type plasminogen activator chain B | PLAU | uPA
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Human
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM50147422
Synonyms:
3-(4-Chloro-1-guanidino-isoquinolin-7-yl)-benzoic acid | CHEMBL111576
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: