Reaction Details Report a problem with these data
Target
GTPase KRas
Ligand
BDBM50648623
Substrate
n/a
Meas. Tech.
ChEMBL_2486813
IC50
2.0±n/a nM
Citation
 Kargbo, RB Innovative Therapeutic Approaches Targeting K-Ras: Analysis of Macrocyclic Compounds, Peptidomimetics, and Pyridopyrimidine Inhibitors. ACS Med Chem Lett 15:1196-1198[PubMed] 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | Ki-Ras | c-K-ras | c-Ki-ras | RASK_HUMAN | KRAS | KRAS2 | RASK2
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Human
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50648623
Synonyms:
CHEMBL5612217
Type:
Small organic molecule
Emp. Form.:
C34H32F6N6O2
Mol. Mass.:
670.66
SMILES:
C#Cc1c(F)ccc2cc(N)cc(-c3ncc4c(N(C)[C@H]5C[C@@H]5F)nc(OCC56CCCN5CC(=C)C6)nc4c3F)c12
Structure:
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