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Target
GTPase KRas
Ligand
BDBM50648625
Substrate
n/a
Meas. Tech.
ChEMBL_2486813
IC50
0.589000±n/a nM
Citation
 Kargbo, RB Innovative Therapeutic Approaches Targeting K-Ras: Analysis of Macrocyclic Compounds, Peptidomimetics, and Pyridopyrimidine Inhibitors. ACS Med Chem Lett 15:1196-1198[PubMed] 
Target
Name:
GTPase KRas
Synonyms:
GTPase KRas, N-terminally processed | K-Ras 2 | Ki-Ras | c-K-ras | c-Ki-ras | RASK_HUMAN | KRAS | KRAS2 | RASK2
Type:
PROTEIN
Mol. Mass.:
21656.10
Organism:
Human
Description:
ChEMBL_1476955
Residue:
189
Sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM50648625
Synonyms:
CHEMBL5613663
Type:
Small organic molecule
Emp. Form.:
C32H28F3N5O2
Mol. Mass.:
571.60
SMILES:
C#Cc1c(F)ccc2cc(O)cc(-c3ncc4c(N(C)[C@H]5C[C@@H]5F)nc(OC[C@]56CCCN5CC(=C)C6)nc4c3F)c12
Structure:
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